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Leveraging BCMA-Directed Therapies for Improved Patient Outcomes in Relapsed/Refractory Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a disease that remains incurable for most patients, many of whom become refractory to the majority of available treatments (Kumar et al, 2022). It is estimated that 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Agents targeting B-cell maturation antigen (BCMA), including antibody-drug conjugates (ADCs), chimeric antigen receptor (CAR) T-cell therapies, and bis... |
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Hitting the Target in HER2-Positive Metastatic Colorectal Cancer
STATEMENT OF NEED
An estimated 153,020 new cases of colorectal cancer (CRC) are diagnosed annually, and 52,550 people die of the disease (Siegel et al, 2023). Approximately 22% of patients present with metastatic disease, which is associated with a dismal 5-year survival rate of 15% (SEER, 2022). Targeting biomarkers is a key strategy for expanding therapeutic options and improving outcomes in metastatic CRC. Human epidermal growth factor receptor 2 (HER2) amplification status and treatment... |
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Expert Guidance on Current Standards and New Directions in Newly Diagnosed Multiple Myeloma
STATEMENT OF NEED
An estimated 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Characterized by clonal proliferation of malignant plasma cells in the bone marrow, multiple myeloma is associated with anemia, renal insufficiency, bone destruction, and hypercalcemia, all of which significantly impact patients’ quality of life. The development of novel therapies and combinations in recent years, inclu... |
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Myasthenia Gravis Research Highlights: AAN 2023
This 30-minute CME program highlights the latest clinical research about myasthenia gravis, a rare, autoimmune disease that targets the neuromuscular junction.
Treatment of myasthenia gravis is highly individualized and depends greatly on the myasthenia gravis subtype of each patient as well as each patient’s comorbidities. There are currently four drugs approved by the FDA, eculizumab, efgartigimod, ravulizumab, and rozanolixizumab. There are also treatments in development. Clinical tria... |
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Leveraging the Growing Arsenal of Adjuvant Therapies for Early-Stage NSCLC
In this activity, Dr. Helena A. Yu, Associate Attending Physician at Memorial Sloan Kettering Cancer Center, will provide insights into strategies for leveraging the growing arsenal of adjuvant therapies for early-stage non"small cell lung cancer (NSCLC), including treatment selection and adverse event management. Start the activity now!
STATEMENT OF NEED
Lung cancer is the second most commonly diagnosed cancer and the leading cause of death for men and women worldwide. In the Unite... |
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Pathology and Oncology Expert Perspectives in the Management of Triple-Negative Breast Cancer: Case Explorations and Answers to FAQs
STATEMENT OF NEED
Triple-negative breast cancer (TNBC) is an aggressive disease that accounts for approximately 10% to 15% of breast cancer diagnoses and is characterized by the absence of estrogen receptors, progesterone receptors, and human epidermal growth factor receptor 2 (HER2). TNBC is more common in Black women and in women under the age of 40 (ACS, 2023). Compared with other subtypes of invasive breast cancer, TNBC has high rates of metastasis and a poor prognosis. Due to the lack ... |
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Putting the Freeze on Cold Agglutinin Disease
STATEMENT OF NEED
Cold agglutinin disease (CAD) is a rare subtype of autoimmune hemolytic anemia (AIHA) in which antibodies cause hemolysis at cold temperatures, generally between 37º to 39º Fahrenheit. Approximately 1 in a million people are affected by CAD annually, with onset usually occurring between the ages of 40 and 80 years. Individuals commonly experience fatigue, dizziness, palpitations, and shortness of breath caused by the anemia; jaundice caused by degradation of hemoglobin i... |
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Acromegaly Research Highlights: ENDO 2023
This 30-minute CME-accredited program highlights the latest clinical research about acromegaly, a rare endocrine disorder. Common symptoms include subtle skeletal overgrowth; soft tissue swelling (tongue, heart, kidney, colon, and vocal cords); unusually prominent forehead and heavy brow ridge; protruding lower jaw; overbite; skin thickening; increased shoe and ring size; hypertension; increased perspiration; headaches; paresthesia; and sexual dysfunction.
There are several orphan drugs app... |
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Managing Immune Related Adverse Events to Ensure Optimal Cancer Immunotherapy Outcomes: The Nurse’s View
STATEMENT OF NEED
Immune checkpoint inhibitors, which alter immune regulatory pathways and promote cell-mediated destruction of tumor cells, have revolutionized the treatment of cancer in recent years, with numerous therapeutic agents approved and several targets under investigation (Chennamadhavuni et al, 2022). However, up to 90% of patients receiving immune checkpoint inhibitors experience immune-related adverse events, which can affect a wide variety of organ systems and can occur at any ... |
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Cushing’s Disease Research Highlights: ENDO 2023
This 30-minute CME program highlights the latest clinical research about Cushing’s disease.
Cushing’s disease is caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary tumor that leads to excessive levels of cortisol.
This CME program, hosted by Lisa Machtigall, MD, Clinical Director, Neuroendocrine & Pituitary Tumor Clinical Center at Massachusetts General Hospital, and Associate Professor of Medicine at Harvard Medical School, provides an overview of the latest cli... |
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New Guidance to Diagnose and Treat Tumor-induced Osteomalacia (TIO)
This 30-minute CME-accredited program, hosted by Aliya Khan, MD, Clinical Professor of Medicine at McMaster University, highlights the best practices to diagnose and treat tumor induced osteomalacia (TIO) based on the recently published global guidance document in the Journal of Internal Medicine.
This activity has been designed to meet the educational needs of physicians specializing in neurology, orthopedics, internal medicine/general practice, rheumatology, endocrinology, pain management... |
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Exploring New Treatment Advances for Acid Sphingomyelinase Deficiency in Adults
STATEMENT OF NEED
Acid sphingomyelinase deficiency (ASMD) is a rare, hereditary lysosomal storage disease with multisystemic manifestations, including splenomegaly, hepatomegaly, interstitial lung disease, dyslipidemia, bone marrow and lymph node involvement, and sometimes neurological and peripheral nerve involvement. While the most severe form of ASMD, infantile neurovisceral ASMD, results in death in early childhood, chronic forms of ASMD have more prolonged survival but are associated w... |
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Recurrent and Metastatic HNSCC: New Insights and Real-World Evidence for Improved Patient Outcomes
STATEMENT OF NEED
Head and neck cancers represent a heterogeneous group of tumors that originate in the lip/oral cavity, hypopharynx, oropharynx, nasopharynx, and larynx. An estimated 66,470 new cases are diagnosed in the United States annually, and 15,050 people die of the disease (Siegel et al, 2022). Approximately 90% of cases are classified as head and neck squamous cell carcinoma (HNSCC). Treatment of HNSCC is complicated by numerous factors, including differing therapeutic strategies ... |
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Exploring Novel Treatments for Rett Syndrome
STATEMENT OF NEED
Rett syndrome is a rare, debilitating neurodevelopmental disorder almost always associated with a spontaneous mutation in the methyl-CpG-binding protein 2 (MECP2) gene on the X-chromosome. Affected individuals experience loss of purposeful hand skills, abnormalities in gait, loss of spoken language, and stereotypic hand movements, with more severe manifestations including seizures, autistic features, autonomic nervous system dysfunction, breathing abnormalities, sleep dist... |
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Advancing the Care of Patients Living with EGPA Through Multidisciplinary, Patient-Focused Care
Target Audience
This educational activity is intended for rheumatologists, allergists, immunologists, pulmonologists, and specialty advance practice clinicians who care for patients with EGPA.
Program Overview
The comprehensive program provides up-to-date information regarding EGPA"its recognition, diagnosis, and treatment"and incorporates the patient perspective to raise awareness of patients’ needs, heighten urgency, and, ultimately, educate on the disease. The program will ... |
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The Safety of Opioid Use in Chronic Obstructive Pulmonary Disease
This session will evaluate the safety of opioid therapy among patients with chronic obstructive pulmonary disease (COPD). The session will cover existing safety and effectiveness evidence from clinical trials, and present the latest data from observational studies. The presentation will include a discussion of the strengths and disadvantages of observational study designs along with implications for future practice.
Approximately 15.7 million Americans (6.4%) currently are diagnosed with CO... |
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Right Treatment, Right Patient: Evidence-Based Approaches to the Treatment of Moderate-to-Severe Atopic Dermatitis Snippet 1: Currently Available Injectable Biologic Therapies for Moderate-to-Severe Atopic Dermatitis (AD)
Target Audience
This activity is designed to meet the educational needs of dermatology and allergy physicians, nurse practitioners, PAs, and nurses who care for patients with moderate-to-severe atopic dermatitis.
Program Overview
This activity features a case presentation, a brief overview of currently available injectable biologic therapies, and insights from an expert faculty.
Learning Objectives
After completing this activity, the participant should be better able to::
Identify ... |
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Infectious Diseases in Adults 2024 - LIVE STREAMING
State-of-the-art approaches to prevention, diagnosis, and treatment of infectious diseases
This comprehensive Harvard Medical School CME program"one of the highest-rated HMS CME courses"ensures attendees are current with state-of-the-art approaches to prevention, detection, diagnosis, and treatment of infectious diseases. Updates, best practices and new guidelines are presented by nationally recognized ID experts and master clinicians. Education is practical and results driven:
... |
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Geographic Atrophy: Rapid Response from ARVO
Geographic atrophy (GA) is a pathological deterioration of the retina seen in the late stages of age-related macular degeneration (AMD). It affects 20% of people with AMD, and its prevalence increases exponentially with age. Until recently, there were no treatment options for GA, but investigation into the complement system and its role in the pathogenesis of GA has led to targeted therapies that have revolutionized the treatment paradigm. Because of the recent approval of one of these therapi... |
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Parkinson’s Disease " Updates in Diagnosis and Patient Management
Parkinson's disease is a neurodegenerative disorder, second only in prevalence to Alzheimer’s disease. Numerous therapeutic options, including carbidopa/levodopa, monoamine oxidase-B inhibitors, dopamine agonists, and device-assisted therapies, are available for treatment. These treatments are indicated at different stages following diagnosis. However, Parkinson’s disease progresses at highly variable rates, and no biomarkers, laboratory tests, or gold standard indexes are available t... |
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Diabetes Update 2024 - LIVE STREAMING
This highly rated Harvard Medical School CME course offers practical strategies to address the medical and systemic challenges to optimal care and updates that ensure you can deliver state-of-the-art care for your patients with diabetes.
PROGRAM HIGHLIGHTS
This program affords you the opportunity to learn from leaders in the field of diabetes who are distinguished for their outstanding teaching, knowledge, and innovations in clinical care.
Participants can rely on this program for compreh... |
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The HIV Journey Staying the Course Through Critical Junctions in Care
HIV is a life-long condition that is becoming increasingly complex. Clinicians must be prepared to face myriad situations over a patient’s lifespan, relating both to their HIV and to either other comorbidities or issues such as stigma or social determinants of health. In this interactive activity, you will follow a patient diagnosed as an adolescent through his lifespan with HIV to make decisions about common challenges. Dr. Onyema Ogbuagu will review rapid ART, educating adolescents, addres... |
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Hot Topics in Lupus: SLE Pathophysiology
Despite the known short- and long-term adverse outcomes related to glucocorticoid use, patients with SLE are still taking moderate to high daily doses of steroids. Fortunately, 2 biologic therapies aimed at different therapeutic targets in the type I interferon pathway and with better safety profiles than glucocorticoids are currently available for use. These biologics, along with off-label immunosuppressants, can be implemented in customized ways to mitigate or eliminate the use of glucocort... |
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Hot Topics in Lupus: Individualizing Steroid-Sparing Regimens
Despite the known short- and long-term adverse outcomes related to glucocorticoid use, patients with SLE are still taking moderate to high daily doses of steroids. Fortunately, 2 biologic therapies aimed at different therapeutic targets in the type I interferon pathway and with better safety profiles than glucocorticoids are currently available for use. These biologics, along with off-label immunosuppressants, can be implemented in customized ways to mitigate or eliminate the use of glucocort... |
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Hot Topics in Lupus: Targeted Biologic Treatment Options
Despite the known short- and long-term adverse outcomes related to glucocorticoid use, patients with SLE are still taking moderate to high daily doses of steroids. Fortunately, 2 biologic therapies aimed at different therapeutic targets in the type I interferon pathway and with better safety profiles than glucocorticoids are currently available for use. These biologics, along with off-label immunosuppressants, can be implemented in customized ways to mitigate or eliminate the use of glucocort... |
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EGPA Expert Exchange " A Podcast Series on Eosinophilic Granulomatosis With Polyangiitis
Eosinophilic granulomatosis with polyangiitis (EGPA), formerly called Churg-Strauss syndrome, is a rare form of vasculitis that primarily affects the small blood vessels. Individuals diagnosed with EGPA commonly have a history of asthma and/or allergies. Eosinophilic inflammation associated with EGPA can lead to injury in multiple organ systems, including the sinuses, lungs, gastrointestinal system, heart, nervous system, and kidneys. Accurate diagnosis and treatment are critical to minimize g... |
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Innovations and New Practices in Internal Medicine 2024 -LIVE STREAMING
The State of the Art in Internal Medicine
This program, which is among the highest-rated Harvard Medical School CME courses, provides a comprehensive update of the most important changes now impacting Internal Medicine and guidance on how to incorporate these changes into your clinical practice to improve patient outcomes..
Practical, Fast-Paced, Online Education
This live streaming educational experience is fast paced, relevant to the current healthcare environment, and draws upon real... |
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NeuroRehabilitation 2024 - LIVE STREAMING
Comprehensive Neurorehabilitation Update
Cutting-edge strategies, updates, and best practices for state-of-the-art rehabilitation
In this course, which is among the highest-rated Harvard Medical School CME courses, many of the country’s most experienced and committed neurorehabilitation experts will present cutting-edge clinical interventions, the latest findings, practical education, and hands-on methods to further your expertise in guiding your patients with stroke, SCI, TBI, brain t... |
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Is It Safe? Safety Surveillance through the Antiretroviral Pregnancy Registry
Is It Safe? Safety Surveillance through the Antiretroviral Pregnancy Registry
Release Date: June 2, 2023
Expiration Date: June 2, 2024
Estimated Time to Complete: 1.25 hour
VIEW ACTIVITY
Clinical Gap and Educational Need
Antiretroviral therapy should be initiated for all persons with HIV who are pregnant regardless of CD4 count according to current guidelines. There is often minimal data available to make recommendations, however, for use in pregnancy. One key consideration is... |
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Graft vs Host Disease: Novel Management Strategies for a Chronic Condition
Target Audience
The intended audience for this activity is transplant specialists, oncologists, hematologists, and other healthcare professionals involved in the treatment of patients with GVHD.
Program Overview
This enduring activity takes learners on a compelling journey in managing chronic graft-versus-host disease (cGVHD) by explaining the evidence-based diagnostic criteria for cGVHD for prompt diagnosis; discussing the clinical safety and efficacy data of recently approved and invest... |
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A Breath of Fresh Air: Novel Treatments That Address the Inflammatory Component of Non-Cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFBE) is a heterogenous and increasingly prevalent chronic pulmonary disease that is associated with high morbidity and mortality. It is characterized by irreversibly damaged and dilated bronchi, and has a broad spectrum of clinical presentations, ranging from asymptomatic radiological changes detected incidentally to chronic sputum production and recurrent exacerbations. There are numerous etiologies that can induce or contribute to the pathophysiological ... |
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In Case You Missed: Utilizing the Muscarinic System to Optimize Treatment Options for Schizophrenia
Schizophrenia is an incurable, neuropsychiatric disease characterized by difficulties thinking and communicating clearly as well as psychosis (ie, “positive” symptoms); difficulty functioning socially (ie, “negative” symptoms); and cognitive impairment. As many as 34% of patients with schizophrenia have treatment-resistant schizophrenia, defined as continuing symptoms despite at least 2 trials of appropriate antipsychotic treatment, and most people do not recover from it. Patients with... |
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28th Annual Hypertension, Diabetes & Dyslipidemia Conference
This three day intensive conference, held on June 19-21, 2024 in Charleston, South Carolina, addresses all the issues confronting clinicians who treat challenging patients with diabetes, hypertension, and dyslipidemia and how to apply this knowledge to everyday practice.
Over the past several years controversies in the appropriate target for Hemoglobin A1C, BP, and LDL-Cholesterol on outcome improvement continue to occur in Type 2 diabetes, Hypertension, and Dyslipidemia, respectively. Desp... |
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Managing Thyroid Eye Disease: Rapid Response From ENDO
For a timely diagnosis and optimal management of thyroid eye disease (TED), a multidisciplinary team of endocrinologists, ophthalmologists, oculoplastic surgeons, as well as other healthcare professionals is essential. Early diagnosis of TED through imaging and clinical assessment is imperative to allow for the timely initiation of therapeutic strategies that limit disfiguration and reduce the potential for vision loss. The recent updates to guidelines for the management of TED, along with the... |
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Build Your Own Case Study | Obesity: Treating the Whole Patient
Activity Description
Obesity is a chronic, progressive, relapsing disease that impacts health and quality of life. In individuals with obesity, there are many contributors to its development and persistence, including lifestyle, social, and economic factors. If left untreated, obesity can be a primary driver of serious health consequences. By treating obesity first, complications arising from obesity may improve or resolve. Given the severity of the disease, there is a need for clinicians in ... |
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Answering the Call in Severe Asthma Expanding Roles for Biologic Treatment Regimens
This enduring Call-a-Colleague™ educational program will guide attendees through the long-term management of severe asthma. Expert faculty will provide actionable recommendations on evaluation strategies that consider underlying mechanism of disease, data on newer biologic treatment options, and most importantly, the use of these therapies in current day practice. Interspersed throughout the program are brief Call-a-Colleague™ video calls in which faculty consult with their specialist coll... |
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Ace the Case: A 65-Year-Old Woman With Chronic Diabetic Macular Edema in Both Eyes
In this clinical case review, Dr. Sara Haug explores considerations for the management of a patient with DME who is receiving monthly anti-VEGF therapy without attaining disease control. |
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Emerging Therapies, Novel Mechanisms, and New Hope in the Treatment of PAH
The treatment landscape of pulmonary arterial hypertension (PAH) is poised to change dramatically in the near future. Designed with your questions in mind, this digital FAQ index offers succinct and relevant information for all practicing pulmonology and cardiology learners. What are some of the emerging therapies for PAH, and how do they differ from current treatment options? Which emerging therapies may be disease modifying? What clinical trial evidence is there for the treatments being inve... |
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Gastroenterology 2024 - LIVE STREAMING
The Comprehensive 2024 Gastroenterology Update
This highly rated Harvard Medical School CME program ensures participants are current with state-of-the-art GI strategies and clinical practices. It covers recent advances and their impact on clinical approaches and on patient outcomes. Updates, best practices, and new guidelines are presented by nationally recognized GI experts and master clinicians.
Practical, Results-Driven Education
Highlights of the 2024 program include:
• Updated... |
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Internal Medicine Comprehensive Review and Update 2024 - LIVE STREAMING
Comprehensive, Evidence-Based Updates for Internal Medicine and Its Subspecialties
This program, the 64th annual Internal Medicine Update from the leading clinical faculty of Harvard Medical School and Massachusetts General Hospital, provides comprehensive, high-yield instruction to ensure clinicians are current with the latest evidence and best practices to optimize patient care.
This program covers the breadth of Internal Medicine subspecialties, including:
• Cardiovascular Medicine
... |
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Neuromyelitis Optica Spectrum Disorder: Updates on Diagnosis and Treatment Management
Neuromyelitis optica spectrum disorder (NMOSD) is a rare, relapsing, autoimmune disease of the central nervous system that is characterized by inflammation in the optic nerve and spinal cord. Unfortunately, early stages of NMOSD are frequently misdiagnosed as multiple sclerosis or other diseases. Diagnosis is typically based on the presence of key clinical characteristics"aquaporin-4 (AQP4) antibody status and magnetic resonance imaging. The application of newer diagnostic criteria may as... |
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Right Treatment, Right Patient: Evidence-Based Approaches to the Treatment of Moderate-to-Severe Atopic Dermatitis Snippet 2: Currently Available Oral Therapies for Moderate-to-Severe Atopic Dermatiti
Target Audience
This activity is designed to meet the educational needs of dermatology and allergy physicians, nurse practitioners, PAs, and nurses who care for patients with moderate-to-severe atopic dermatitis.
Program Overview
This activity features a case presentation, a brief overview of currently available oral therapies, and insights from expert faculty.
Learning Objectives
After completing this activity, the participant should be better able to::
Identify the biologic prope... |
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Call to Action for Health Equity: Racial Disparities in the Care of Patients with Cardiometabolic Disease
Cardiovascular disease is the leading cause of death for adults in the US. However, patients from minority populations with cardiovascular disease have disproportionately poor health outcomes and are particularly vulnerable to health disparities. Racial inequities in health also result in higher risk-burden in minority groups for metabolic syndromes such as Type 2 (adult-onset) diabetes, which increase the risk of cardiovascular disease. Health disparities in cardiometabolic care predominantly... |
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Making the Call in Nonadvanced Systemic Mastocytosis Optimizing Multidisciplinary Management
Series Overview
Nonadvanced systemic mastocytosis (SM) is a group of rare disorders characterized by mast cell accumulation that results in a significant and varied symptomatic burden to the patient. The most prevalent of these symptoms include gastrointestinal symptoms, dermatological symptoms, and recurrent anaphylaxis in response to a variety of triggers such as food, insect venom, and medications. In this Phone-a-Friend series, a multidisciplinary panel of faculty experts will address the... |
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Rheumatology 101 for the Primary Care Clinician
The Pacific Northwest is experiencing a critical shortage of rheumatologists. Despite efforts from multiple organizations, including the American College of Rheumatology, The Arthritis Foundation, The University of Washington, and Virginia Mason Medical Center, Washington State continues to rank near the bottom for access issues. In a May 2022 interview, Washington Rheumatology Alliance (WRA) President Jeff Peterson, MD noted with concern that rural patients are particularly underserved, with ... |
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Applying Guidelines and Latest Evidence to the Management of Moderate‐to‐Severe Asthma in Children and Adults
Target Audience
The educational design of this activity addresses the needs of pulmonologists, allergists/immunologists, NPs and PAs, and other clinicians involved in the management of patients with moderate‐to‐severe asthma.
Program Overview
Patients with asthma and underlying comorbidities require personalized treatment to achieve asthma control. Children with asthma have an especially high burden of symptoms, and are at risk of impaired lung development if asthma control cannot be ... |
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Answers to the Questions You May Not be Asking: Treating Ulcerative Colitis Considerate of Patient-Centric Factors
Are you aware of the latest evidence-based strategies in ulcerative colitis (UC)? Looking to expand your ability to incorporate patient-centric factors into selection of therapy for UC? Navigate through this novel, interactive self-directed activity designed to optimize your decision making in selection of therapy for UC. View expert perspectives and insights who can help you apply newer strategies such as treat-to-target (T2T) and therapeutic drug monitoring (TDM) for the treatment for your ... |
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Contemporary Management of Patients with Systemic Lupus Erythematosus: A Case-based Approac
This modular continuing education activity provides an update on the epidemiology, monitoring, and treatment of patients with systemic lupus erythematosus (SLE). Diane Kamen, MD, and Anca Askanase, MD, examine the current research on demographic groups with an increased risk of SLE and its severe complications, including lupus nephritis (LN). They also review the application of the most current treatment goals and classification criteria to speed diagnosis and guide disease activity monitorin... |
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Case Studies in Hereditary Angioedema: Moving Beyond Crisis to Long-Term Prevention
Hereditary angioedema (HAE) is an autosomal dominant condition that causes recurring, unpredictable, and potentially fatal attacks resulting in a profound disease burden and diminished health-related quality of life (QoL). Recent advances have led to new therapies for HAE, including long-acting prophylactic therapies that have improved efficacy, tolerability, and convenience, compared to earlier treatments. Many health care providers are unaware of HAE and its diagnosis, particularly the diffe... |
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Top 10 COVID-19 Special Population Queries
Even though the COVID-19 pandemic is slowly becoming endemic, there are still certain populations at higher risk of progressing to severe COVID-19 should they become infected with SARS-CoV-2. These include immunocompromised groups, older patients, patients with HIV, disabilities, challenges in social determinants of health, and racial or ethnic minorities. There are treatment considerations for many of these populations, including drug-drug interactions. In this self-directed activity, Drs. Gl... |
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