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Leveraging BCMA-Directed Therapies for Improved Patient Outcomes in Relapsed/Refractory Multiple Myeloma
STATEMENT OF NEED
Multiple myeloma is a disease that remains incurable for most patients, many of whom become refractory to the majority of available treatments (Kumar et al, 2022). It is estimated that 35,730 new cases of multiple myeloma are diagnosed in the United States annually, and 12,590 people die of the disease (Siegel et al, 2023). Agents targeting B-cell maturation antigen (BCMA), including antibody-drug conjugates (ADCs), chimeric antigen receptor (CAR) T-cell therapies, and bis... |
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Exploring New Treatment Advances for Acid Sphingomyelinase Deficiency in Adults
STATEMENT OF NEED
Acid sphingomyelinase deficiency (ASMD) is a rare, hereditary lysosomal storage disease with multisystemic manifestations, including splenomegaly, hepatomegaly, interstitial lung disease, dyslipidemia, bone marrow and lymph node involvement, and sometimes neurological and peripheral nerve involvement. While the most severe form of ASMD, infantile neurovisceral ASMD, results in death in early childhood, chronic forms of ASMD have more prolonged survival but are associated w... |
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Operation Game- A Patient’s Journey Through HeFH: Diagnosis and Management
Target Audience
This activity has been designed to address the educational needs of cardiologists, cardiology nurses, lipid specialists, and primary care clinicians, including internists, pharmacists, nurses, nurse practitioners, PAs, and dietitians. It may also benefit other healthcare providers who manage patients with hypercholesterolemia.
Program Overview
Nonstatins are an essential therapy for lowering low-density lipoprotein cholesterol (LDL-C) levels in high-risk patients, such as ... |
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INFORM: Information Needed for Optimal Regulation of Mycophenolate- A REMS Activity
Target Audience
The target audience for this initiative includes obstetricians, gynecologists, primary care physicians, physician assistants, nurse practitioners, pharmacists, and care team members involved in the treatment of women across their reproductive lifespan who may have been prescribed mycophenolate products.
Program Overview
Clinicians who work with women of childbearing age who are, or will be, taking mycophenolate must ensure that their patients receive appropriate counseling... |
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The HIV Journey Staying the Course Through Critical Junctions in Care
HIV is a life-long condition that is becoming increasingly complex. Clinicians must be prepared to face myriad situations over a patient’s lifespan, relating both to their HIV and to either other comorbidities or issues such as stigma or social determinants of health. In this interactive activity, you will follow a patient diagnosed as an adolescent through his lifespan with HIV to make decisions about common challenges. Dr. Onyema Ogbuagu will review rapid ART, educating adolescents, addres... |
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Is It Safe? Safety Surveillance through the Antiretroviral Pregnancy Registry
Is It Safe? Safety Surveillance through the Antiretroviral Pregnancy Registry
Release Date: June 2, 2023
Expiration Date: June 2, 2024
Estimated Time to Complete: 1.25 hour
VIEW ACTIVITY
Clinical Gap and Educational Need
Antiretroviral therapy should be initiated for all persons with HIV who are pregnant regardless of CD4 count according to current guidelines. There is often minimal data available to make recommendations, however, for use in pregnancy. One key consideration is... |
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Meeting Milestones in nAMD and DME Management: What's New?
Anti-vascular endothelial growth factor (VEGF) therapy has revolutionized treatment paradigms for neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). However, these agents are associated with a high treatment burden because of the injection frequency, and a substantial number of patients do not adhere to their treatment schedules, resulting in suboptimal response to therapy. To address these issues, new dosage regimens and surgical drug delivery approaches hav... |
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A Breath of Fresh Air: Novel Treatments That Address the Inflammatory Component of Non-Cystic Fibrosis Bronchiectasis
Non-cystic fibrosis bronchiectasis (NCFBE) is a heterogenous and increasingly prevalent chronic pulmonary disease that is associated with high morbidity and mortality. It is characterized by irreversibly damaged and dilated bronchi, and has a broad spectrum of clinical presentations, ranging from asymptomatic radiological changes detected incidentally to chronic sputum production and recurrent exacerbations. There are numerous etiologies that can induce or contribute to the pathophysiological ... |
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HIV Snippets " A Podcast Series: Optimizing Care in HIV Treatment and Prevention
Antiretroviral therapy (ART) for treating HIV has improved dramatically over the past decade. This progress has yielded more treatment choices for clinicians and patients but also adds greater complexity to the already-diverse field of HIV treatment. In this CE activity, participants will listen to expert faculty in a series of 4 podcasts. The faculty will explore various aspects of HIV management, including geographic disparities in pre-exposure prophylaxis (PrEP) implementation, use of 3-dru... |
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Answers to the Questions You May Not be Asking: Treating Ulcerative Colitis Considerate of Patient-Centric Factors
Are you aware of the latest evidence-based strategies in ulcerative colitis (UC)? Looking to expand your ability to incorporate patient-centric factors into selection of therapy for UC? Navigate through this novel, interactive self-directed activity designed to optimize your decision making in selection of therapy for UC. View expert perspectives and insights who can help you apply newer strategies such as treat-to-target (T2T) and therapeutic drug monitoring (TDM) for the treatment for your ... |
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Top 10 COVID-19 Special Population Queries
Even though the COVID-19 pandemic is slowly becoming endemic, there are still certain populations at higher risk of progressing to severe COVID-19 should they become infected with SARS-CoV-2. These include immunocompromised groups, older patients, patients with HIV, disabilities, challenges in social determinants of health, and racial or ethnic minorities. There are treatment considerations for many of these populations, including drug-drug interactions. In this self-directed activity, Drs. Gl... |
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Prurigo Nodularis: Recognizing, Diagnosing and Treating a Rare but Debilitating Disease
Prurigo Nodularis is a rare, chronic skin disorder that causes substantial patient burden, but is often overlooked or misdiagnosed and, until recently, had no medications approved by the US Food and Drug Administration. The interprofessional faculty share their real-world perspectives on the diagnosis and treatment of patients with prurigo nodularis to reduce patient burden of disease and improve health outcomes. Highlighting pathophysiologic mechanisms, the faculty discuss the evolving pharma... |
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Putting Together Clues in HIV, CVD, T2D, and CKD
As people with HIV live longer, they can develop common comorbidities affecting aging patients, such as type 2 diabetes (T2D), cardiovascular disease (CVD), and chronic kidney disease (CKD). Further, weight gain may be seen in some patients, though the role of antiretroviral therapy (ART) is still under investigation. Clinicians should become familiar with treatment guidelines, drug-drug interactions, and techniques for shared decision-making to manage aging patients with HIV and common comorb... |
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Case Studies in HIV Prevention and Treatment of Persons Who Use Drugs
Educational Need:
Prevention of HIV in individuals with substance use disorder (SUD) is vitally important from a public health perspective. People with SUD are significantly more vulnerable to contracting HIV, attributable to behaviors such as sharing needles and injection equipment, engaging in condomless sex, and impaired judgement. Furthermore, substance use can negatively affect medication adherence and engagement in healthcare, making it more challenging to treat and manage HIV in this ... |
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CME Escape Room: Putting Together Clues in HIV, CVD, T2D, and CKD: Escaping Management Mishaps
Target Audience
The educational design of this activity addresses the needs of US and ex-US infectious disease and HIV specialist physicians, NPs, and PAs involved in the treatment of patients with HIV.
Program Overview
As people with HIV live longer, they can develop common comorbidities affecting aging patients, such as type 2 diabetes (T2D), cardiovascular disease (CVD), and chronic kidney disease (CKD). Further, weight gain may be seen in some patients, though the role of antiretrovir... |
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Ace the Case: Pulmonary Arterial Hypertension (PAH) Presentation and Evaluation by Pulmonary Specialist
Pulmonary hypertension (PH) comprises a heterogeneous group of disorders that share a common clinical feature - mean pulmonary artery pressure greater than 20 mm Hg. PH may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases. Early diagnosis is critical to ensure patients are eligible for the widest spectrum of treatment options and that treatment is initiated as early as possible in the disease process. PH is classified into 5 c... |
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Ace the Case: Pulmonary Arterial Hypertension (PAH) Treatment Decisions and Therapy Initiation by Pulmonary Hypertension Specialist
Pulmonary hypertension (PH) comprises a heterogeneous group of disorders that share a common clinical feature - mean pulmonary artery pressure greater than 20 mm Hg. PH may involve multiple clinical conditions and may be associated with a variety of cardiovascular and respiratory diseases. Early diagnosis is critical to ensure patients are eligible for the widest spectrum of treatment options and that treatment is initiated as early as possible in the disease process. PH is classified into 5 c... |
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Recognition and Referral: Best Practices for Managing Patients with GA
Patients with advanced dry age-related macular degeneration can present with geographic atrophy (GA), a disease that is progressive and increases with age. Although there is no treatment approved by the FDA that halts or reverses GA, a number of drugs in the pipeline are designed to address GA progression, hoping to succeed where previous drug candidates failed. This series of regional, interactive, virtual symposia are designed to educate eye care providers on the importance of diagnosis and ... |
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Case Studies in HIV Resistance Testing and Treatment " Experienced Patients
Educational Need:
Through a series of patient cases, participants will explore the complexities of managing HIV infection in patients who have been treated with multiple different HIV regimens. Participants will engage in real-life case studies that will provide valuable insight into the intricacies of HIV treatment and resistance testing. Our faculty educators will discuss commonly encountered challenges faced by the care team and their treatment-experienced patients with HIV and offer real... |
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Physical Assessment - A Certificate Training Workshop for Pharmacy Practitioners
As pharmacists expand their scope of practice under
new legislation (SB493), physical assessment is a key
skill necessary for advanced practice. This 21 hour
course will prepare the pharmacist to obtain a
history and perform a basic physical examination
that will enable them to assess and monitor drug
therapy. The course will employ written materials,
videos, lectures, demonstrations and hands on
practice and feedback
Objectives for Pharmacists
At the conclusion of the course the p... |
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Biosimilars in Osteoporosis: Highlights from the ASBMR
Biosimilars are large, complex molecules made from living organisms that are highly similar to their reference biologic and are administered in the same way, with the same strength and dosage, and clinically meaningful differences in safety, purity, and potency.
Incorporating biosimilars into the management of osteoporosis, known as a silent chronic disease responsible for 13 million fragility fractures worldwide, provide a more affordable version of osteoporosis medication, and an alternat... |
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