Navigating the Recent Rheumatoid Arthritis Guidelines to Achieve Disease Remission and Reduce Patient

Roy M. Fleischmann, MD, discusses the latest evidence for the management of patients with moderate-to-severe rheumatoid arthritis who do not achieve treatment goals with initial disease-modifying anti-rheumatic drug therapy. A key treatment principle emphasized by Dr. Fleischmann is using a treat-to-target approach guided by validated tools for assessing disease activity and patient-reported outcomes. Among the treatment options, Dr. Fleischmann highlights the pharmacology of the latest approv...
Annenberg Center for Health Sciences at Eisenhower

Navigating Advancements in Diagnosis & Treatment of Axial Spondyloarthritis

More than 80% of the population has significant back pain at some point in their life, with 30% of adults in the United States stating they have chronic low back pain at any given time; 5% of whom have inflammatory back pain. Axial spondyloarthritis (axSpA) affects almost 1.5% of patients with inflammatory back pain; however, the majority of individuals suffering with back pain are not being treated by a rheumatologist, which only exacerbates the challenge to diagnose those with axSpA. Dr....
Annenberg Center for Health Sciences at Eisenhower

Research Developments in Atopic Dermatitis

Welcome to this activity focusing on new research related to atopic dermatitis presented as posters at the 2020 virtual annual meetings of the American Academy of Dermatology and the American Academy of Allergy, Asthma, and Immunology. The posters focus on new data related to the use of advanced therapies for atopic dermatitis. Beyond discussing the methods and results of each poster, the faculty, Drs. Steven Feldman and Alan Fleischer, Jr., share their views on the implication of the trial re...
Annenberg Center for Health Sciences at Eisenhower

Immune Thrombocytopenia: Evolving Treatment Paradigms and Patient-Centered Care

STATEMENT OF NEED Immune thrombocytopenia is an acquired immune-mediated disorder defined as a peripheral blood platelet count
i3 Health

Defining Personalized Care Plans in Metastatic Colorectal Cancer

STATEMENT OF NEED Colorectal cancer (CRC) is the third leading cause of cancer death among men and women in the United States. An estimated 145,600 new cases are diagnosed annually and 51,020 people die of the disease. When detected and treated early at a localized stage, the 5-year survival rate is 90%. However, because CRC initially exhibits no symptoms and the use of routine screening is suboptimal, most patients are diagnosed at later stages. Approximately 21% of patients present with m...
i3 Health

Right Patient, Right Treatment, Right Time: Utilizing Early, High-Efficacy Therapies to Improve Outcomes in RRMS

Recent studies have demonstrated the benefits of early and aggressive treatment strategies in reducing disability progression and the frequency of relapses in patients with relapsing remitting multiple sclerosis (RRMS), marking a paradigm shift in the treatment of patients with RRMS. The traditional escalation approach is now often set aside in favor of the more individualized "induction" approach, which utilizes "early and aggressive" treatment with high-efficacy disease-modifying therapies (...
CME Outfitters

Beyond the Old Paradigms: Novel Approaches to the Treatment of Chronic Idiopathic Constipation

Chronic idiopathic constipation (CIC) affects 35 million adults in the United States, making it one of the most common gastrointestinal disorders. Despite the high prevalence, CIC is often underdiagnosed and undertreated, which exacts a functional, psychosocial, and economic toll on patients and their loved ones. The current treatment goal in CIC is multi-symptom relief, but only 16% of patients with CIC are on prescription therapy, and they often only obtain partial relief, with many using la...
CME Outfitters

Giving Shingles Immunization Your Best Shot: Implementing a Shingles Vaccination Protocol in Your Practice

Shingles, or herpes zoster, is a common secondary infection for older patients. Almost all individuals over the age of 50 are latently infected with varicella zoster virus (VZV) and therefore are at risk of developing shingles with reactivation of latent VZV. Individuals who develop shingles often experience debilitating postherpetic neuralgia (PHN), secondary skin infections, eye problems, or neurologic conditions including an increased risk of stroke. Despite the existence of vaccines, th...
CME Outfitters

Retooling for Modern Management of Progressive MS: An Interactive, Case-Based Activity

The approval of ocrelizumab for primary progressive multiple sclerosis (PPMS) was groundbreaking, and more recently the MS community bore witness to another major breakthrough in MS management when siponimod was approved for secondary progressive MS (SPMS). Additionally, new investigational agents such as MD1003 (high-dose biotin) and masitinib are also being evaluated for treatment of PPMS, and clinical data for both show promise for patients with SPMS. However, despite these advances, stu...
CME Outfitters

Looking Ahead: Integrating Emerging Therapies and Tools in Early-Stage Alzheimer's Disease

Alzheimer's disease (AD), a heterogeneous, neurodegenerative condition with an insidious onset and slow progression, is the leading cause of disability and morbidity as well as the sixth-leading cause of death in the United States. Diagnosing AD is often complicated due to its varied clinical symptomatology and unknown etiology, and currently only symptomatic therapies are available. Recent clinical trials investigating disease-modifying therapies (DMTs) that could slow or reverse the progr...
CME Outfitters

Live Virtual Symposium: The Road to Remission: Assessing Today's Treatment Goals in Crohn's Disease

Crohn’s disease (CD), an inflammatory bowel disease (IBD) that affects at least 780,000 people in the United States, has recently seen its management goals evolve from merely controlling flares to achieving and sustaining deep remission, which can help a patient avoid progressive bowel wall damage. The only treatments effective in achieving durable deep remission are novel targeted therapies, which makes it imperative for clinicians to have a working knowledge of these treatments and to opti...
CME Outfitters

Hitting the Target with IL-23 Inhibitors in Psoriatic Arthiritis

Psoriatic arthritis (PsA) is a chronic, inflammatory, musculoskeletal disease with a significant impact on quality of life and functional ability. Despite the data showing the overall impact of PsA, delays in diagnosis are common, which can lead to long-term joint damage and functional disability. In this CME Outfitters Live and OnDemand activity, expert faculty will focus on assessment, treatment, and management strategies to provide patients with the best treatment aligned with evolving e...
CME Outfitters

Keeping the Beat: Screening and Management of High-Risk Patients with Non-Valvular Atrial Fibrillation

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, projected to affect 12 million Americans by 2030. However, a significant number of AF cases, particularly non-valvular atrial fibrillation (NVAF) remain undiagnosed, putting patients at risk for severe cardiovascular (CV) complications, including increased risk of stroke. It is imperative that clinicians identify the symptomatology of AF and effectively diagnose NVAF, as these complications can potentially be avoided by ...
CME Outfitters

Targeted Therapy for HER2 and HER3-Positive Breast Cancer: Navigating the Evolving Treatment Landscape

Statement of Need Breast cancer (BC) is a heterogeneous disease with human epidermal growth factor receptor 2 (HER2) overexpression and/or amplification observed in 20%-30% of cases. HER2-positive (+) BC correlates with poor clinical outcomes unless appropriately treated with targeted therapy. Despite significant therapeutic advances, many patients experience disease progression with resistance to targeted agents developing over the course of treatment. This CME Outfitters Live and OnDe...
CME Outfitters

Tumor-induced Osteomalacia (TIO): Diagnosis and Management

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic condition commonly characterized by bone pain, muscle weakness and fractures. These tumors secrete excess fibroblast growth factor 23 (FGF23) which inhibits the sodium phosphate renal co-transporters and suppresses 1α hydroxylase activity, thereby decreasing renal reabsorption and increased urinary phosphate excretion. As a result, unexplainable hypophosphatemia with a variety of musculoskeletal abnormalities are the most common sympto...
CheckRare

Neuroendocrine Tumors (NETs) Research Highlights from ENDO 2020

Although the 2020 Endocrine Society’s annual meeting (ENDO 2020) did not take place as scheduled, abstracts, including new information and data on neuroendocrine tumors (NETs) were published. This CME activity highlights the latest information about NETs from ENDO 2020 and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with these rare diseases.
CheckRare

Exploring Novel Treatment Strategies for Metastatic Colorectal Cancer

STATEMENT OF NEED Colorectal cancer (CRC) is the third leading cause of cancer death among men and women in the United States. An estimated 145,600 new cases are diagnosed annually and 51,020 people die of the disease. When detected and treated early at a localized stage, the 5-year survival rate is 90%. However, because CRC initially exhibits no symptoms and the use of routine screening is suboptimal, most patients are diagnosed at later stages. Approximately 21% of patients present with m...
i3 Health

Clinical Updates and Expert Guidance in Prostate Cancer

STATEMENT OF NEED Prostate cancer is the most common tumor type affecting men in the United States, with an estimated 174,650 new cases reported each year. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be understood and represents a significa...
i3 Health

Virtual Tumor Board: Diagnosis and Management of Myelodysplastic Syndromes

STATEMENT OF NEED Myelodysplastic syndromes (MDS) are a group of heterogeneous hematopoietic disorders derived from an abnormal multipotent progenitor cell, characterized by ineffective hematopoiesis, bone marrow failure, and peripheral blood cytopenias. Survival in MDS ranges from a median of 5.3 years in lower-risk patients to as little as 0.8 years in higher-risk patients. Mortality is usually a result of infection, hemorrhage, and/or iron overload secondary to red blood cell transfusion...
i3 Health

Multiple Myeloma: Enhancing Treatment Tolerability, Adherence, and Patient-Centered Care

STATEMENT OF NEED Multiple myeloma (MM) is a B-cell neoplasm characterized by aberrant expansion of plasma cells within the bone marrow and extramedullary sites (eg, cortical bone). Approximately 32,270 new cases of MM are diagnosed in the United States annually and 12,830 people die of the disease. Although the tumor cells remain primarily within the bone marrow, they can cause a number of complications, including localized bone destruction, anemia, decreased immunity to infection, and kid...
i3 Health

Mucopolysaccharidoses (MPSs) Highlights from WORLDSymposium 2020

At WORLDSymposium 2020, new information and data were presented on Mucopolysaccharidoses (MPSs), a group of genetic lysosomal disorders. This CME activity highlights the latest information about MPSs from WORLDSymposium and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with these rare diseases.
CheckRare

Gaucher Disease Highlights from WORLDSymposium 2020

At WORLDSymposium 2020, new information and data were presented on Gaucher disease, a rare lysosomal storage disorder. This CME/CNE activity highlights the latest information about Gaucher disease from WORLDSymposium and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with this rare disease.
CheckRare

Fabry Disease Highlights from WORLDSymposium 2020

At WORLDSymposium 2020, new information and data were presented on Fabry disease, a rare lysosomal storage disorder. This CME/CNE activity highlights the latest information about Fabry disease from WORLDSymposium and provides expert analysis of its clinical relevance for busy members of the care team in order to help them care for patients with this rare disease.
CheckRare

@MondayNightIBD OnDemand: Addressing the Cases That Challenge Your Practice

Statement of Need Gastroenterologists are trailblazers in health care social media, and #MondayNightIBD (#MNIBD) has harnessed that energy to establish gastroenterologists as not just social media influencers but as clinical practice influencers as well. #MNIBD is not just a weekly social media conversation - it is an international platform that is moving the field forward by crowdsourcing the expertise of leading inflammatory bowel disease (IBD) experts, community clinicians, and patients ...
CME Outfitters

Improving the Quality of Care for Patients with Atopic Dermatitis: Integrating Measurement-Based Tools Into Your Clinical Practice

Statement of Need Attitudes about atopic dermatitis are evolving with the emergence of new and effective treatments. With the average dermatologist having not enjoyed caring for patients with AD for decades, there is little to no consensus in current practice about validated tools to assess and monitor the severity of the diseases and no consistent use of diagnostic or assessment tools. This lack of knowledge and education leads to confusion, poor recognition, and absence of assessment of AD ...
CME Outfitters

Navigating the New Psoriasis Guidelines: Implications for Clinical Practice

Statement of Need: The American Academy of Dermatology (AAD) and the National Psoriasis Foundation (NPF) have recently released new joint guidelines that outline best practices for the management of psoriasis (PsO) with biologics, the need for awareness and attention to comorbidities, and guidelines for pediatric PsO treatment. Clinicians must ensure that they are aware of these guidelines and of strategies to incorporate them into clinical practice, including the integration of biologic ther...
CME Outfitters

At-Risk Patients Hidden in Plain Sight: Real-World Strategies for Screening and Treating Hepatitis B Virus

Statement of Need Chronic hepatitis B virus (HBV) remains a global epidemic, resulting in significant morbidity and mortality. In 2015, there were 257 million people worldwide infected with HBV. In 2016, only 10.5% were diagnosed, with only 16.7% receiving treatment, and without intervention, there are 19 million deaths anticipated by the end of 2020. These numbers are startling as they exist despite the availability of effective treatment, and this is in part due to lack of clinician knowl...
CME Outfitters

A Deeper Dive into NASH Diagnosis and Treatment: An Augmented Reality Experience

Statement of Need Obesity and diabetes are on the rise, leading to an increased prevalence of non-alcoholic fatty liver disease (NAFLD), which in some cases may progress to non-alcoholic steatohepatitis (NASH). NAFLD effects approximately 30% of the U.S. population, with NASH effecting about 5%. NASH comes with a significant risk of progression to advanced liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). Disease models project that the number of individuals with end-stage live...
CME Outfitters

What the Future Holds for NASH: An Augmented Reality Look into Disease Stating and Targeted Therapies

Statement of Need Given the rising prevalence of non-alcoholic fatty liver disease (NAFLD) and the societal and economic burden of its aggressive subtype, non-alcoholic steatohepatitis (NASH), it is important that hepatologists and gastroenterologists are equipped with the latest tools to diagnose NASH. While there are currently no approved therapies for the treatment of NASH, several targeted therapies are being investigated in clinical trials, with high probability of being approved in the ...
CME Outfitters

Nursing Management of Myelofibrosis: Controlling Symptoms and Optimizing Patient Quality of Life

STATEMENT OF NEED Myeloproliferative neoplasms are a heterogeneous group of hematopoietic disorders that includes myelofibrosis, polycythemia vera (PV), and essential thrombocythemia (ET). These malignancies affect approximately 13,000, 134,000, and 148,000 individuals in the United States, respectively. As symptoms do not typically manifest in early stages, patients with MPNs often present with advanced disease. The presence of comorbidities precludes most from potentially curative allogen...
i3 Health

Addressing the Burden of Psoriatic Arthritis: Moving Beyond the Joint

Philip J. Mease, MD, and Alexis R. Ogdie-Beatty, MD, review the pathogenesis and a wide spectrum of clinical features, manifestations, and comorbidities of psoriatic arthritis; talk about classification criteria for PsA and different patient-reported and provider-assessed outcome measures; and discuss treatment recommendations and strategies, as well as various types of current and emerging therapies. Finally, they highlight some of the key issues and challenges of the management of PsA throug...
Annenberg Center for Health Sciences at Eisenhower

Shifting Focus: Individualizing Preventive Therapy for Hereditary Angioedema

William Lumry, MD, FACAAI, discusses the genetic component of HAE and differences among the types of HAE. This activity also includes several eye-opening video clips from patients with HAE who describe how it affects their daily lives. Content Areas: • Burden of disease • Clinical presentation, features • Causes and types • Diagnosis and screening • Approaches to treatment • Preventive treatment • Comprehensive treatment
Annenberg Center for Health Sciences at Eisenhower

Optimizing Personalized Care Plans for Patients With Advanced Non-Small Cell Lung Cancer

STATEMENT OF NEED An estimated 228,150 new cases of lung cancer are reported in the United States annually, and 142,670 people die of the disease. The major subtypes are non-­small cell (84%) and small cell (13%). Most patients with lung cancer are diagnosed at a locally advanced or metastatic stage, making systemic therapy the cornerstone of management. Although 70% of patients receiving first-line classical doublet chemotherapy demonstrate clinical benefit, most develop progressive disea...
i3 Health

PILOTforPulmonary 2019: Data, Insights & Practice

This education provides the opportunity to learn the latest in the management of patients with IPF/ILD. Summaries or abstracts from recent pulmonary meetings will be presented followed by video discussions by expert faculty regarding the implications on the management of patients with IPF/ILD. Skills can then be applied in an interactive case where the learner is challenged to make decisions for the patient.
The France Foundation

New Thinking, New Strategies in Advanced Urothelial Carcinoma

STATEMENT OF NEED Bladder cancer is the sixth most common malignancy among adults in the United States. Approximately 80,470 new cases are diagnosed annually and 17,670 people die of the disease. More than 90% of patients with bladder cancer have the urothelial carcinoma subtype, which has a high rate of recurrence whether it is low or high grade. Approximately half of all bladder cancers are diagnosed in situ, for which the 5-year relative survival rate is 95%. For tumors diagnosed as a lo...
i3 Health

Managing Individuals With Eosinophilic Granulomatosis With Polyangiitis (EGPA)

The goal of this educational initiative is to improve the knowledge and ability of clinicians who may encounter individuals with EGPA to recognize, manage, and treat patients with EGPA. Unfortunately, many clinicians may encounter individuals who are living with undiagnosed Eosinophilic Granulomatosis with Polyangiitis (EGPA). Although these patients could gain benefit from treatment, damage has often already occurred by the time a diagnosis is made and patients have unnecessarily suffered ...
CheckRare

Rare Disease Clinical Trials

When caring for an individual with a rare disease who has exhausted standard treatments or for whom there are no treatments available, exploration of clinical trials, and possibly expanded access programs, may be warranted. However, many care team members and their patients may not know where to begin with these options. In addition, a number of barriers to participation may exist for both the patient and the care team. Clinicians caring for people with rare diseases, therefore, would benefit ...
CheckRare

Enhancing Treatment Experiences in Castration-Resistant Prostate Cancer: The Nurse's View

STATEMENT OF NEED Prostate cancer is the most common tumor type affecting men in the United States, with an estimated 174,650 new cases reported each year. Typically, androgen deprivation therapy is administered for progressive disease. However, castration resistance or unresponsiveness to androgen deprivation therapy or to antiandrogens frequently develops over time. The transition from castration-sensitive to castration-resistant disease has yet to be understood and represents a significa...
i3 Health

Zooming In on the Education and Empowerment of Patients in AMD Care

FDA-approved agents that target vascular endothelial growth factor (VEGF) constitute important elements of optimal management of AMD. Prior authorization (PA) requirements limit patient access to these therapies. Navigating the PA process can be frustrating for patients, and may result in treatment abandonment leading to suboptimal outcomes. Hence, there is a need for patients to become advocates of their treatment choice. The final module of this CME Outfitters Snack series describes step ...
CME Outfitters

Recent Clinical Trial Data on the Safety and Efficacy of Current and Emerging Therapies to Optimize Schizophrenia Management

Safe and effective treatments for schizophrenia are imperative to optimizing personalized therapy, which helps in reducing relapse and promoting functional recovery in patients with schizophrenia. Emerging data on reducing symptoms, maintaining effective therapy over long-term periods, and minimizing treatment-related metabolic side effects can guide clinicians in choosing the best therapies for their patients. In the final episode of the CMEOcast podcast series on schizophrenia, expert facult...
CME Outfitters

Navigating Through the Latest Advances in Monoclonal Antibodies: Translating Evidence to the Care of Patients with Psoriasis

Recent years have seen an increase in the number of therapeutic monoclonal antibodies (mAbs) that are available to treat a variety of conditions caused by immune-mediated chronic inflammation such as psoriasis. Health care professionals are often presented with complex and conflicting information surrounding concepts of mAb production and immunogenicity; therefore, there is a significant need for education in this area, especially as distinguishing the relative clinical efficacy and safety pro...
CME Outfitters

Minimizing the Burden of Prior Authorization in AMD Through Actionable Strategies and Improved Communication

The development of anti–vascular endothelial growth factor (VEGF) agents has revolutionized the treatment of age-related macular degeneration (AMD). Nevertheless, optimal management of AMD is impeded by challenges in access to FDA-approved therapies. Step therapy, a type of prior authorization (PA) instituted by the payer, mandates that more cost-effective therapies be used before more expensive alternatives, in a stepwise approach. However, applying this strategy to vision-threatening disea...
CME Outfitters

Long-Acting Injectables for Schizophrenia: An Effective, Yet Often Underutilized Tool for Rapid Symptom Reduction and Restoration of Function

Schizophrenia is a serious and debilitating disorder that often poses a considerable challenge to clinicians. While long-acting injectables (LAIs) have emerged as a viable means to address patient nonadherence – often a component of schizophrenia management – clinicians often fail to implement the use of LAIs. Many times this is due to clinicians not being aware of updates such as the introduction of LAIs with increased dosing intervals, knowledge that is an important aspect of narrowing p...
CME Outfitters

Keeping the Patient in the Center in AMD Care

Age-related macular degeneration (AMD) is the leading cause of legal blindness in adults over age 50, but the development of agents that target vascular endothelial growth factor (VEGF) has revolutionized its treatment. There are currently two FDA-approved agents (ranibizumab and aflibercept) and one off-label anti-VEGF agent (bevacizumab) being used to treat patients with AMD, and data from emerging anti-VEGF agents have also demonstrated efficacy in improving visual acuity. However, step the...
CME Outfitters

Honing in on the Appeal Process to Improve Access to Anti-VEGF Therapy for Patients with AMD

Step therapy requirements have limited patient access to FDA-approved, anti–vascular endothelial growth factor (VEGF) agents for the treatment of AMD. Prior authorization requests for these therapies are commonly denied. Hence, it is important that clinicians be aware of the approaches to overcome these barriers and implement systematic and clinically supported appeals that ensure uninterrupted anti-VEGF therapy for patients with AMD. In the third module of this CME Outfitters Snack seri...
CME Outfitters

Current and Emerging Therapies for Schizophrenia: How MOA Affects Clinical Outcomes

Clinical trial data that addresses the safety and efficacy of antipsychotics is continuously emerging, with a focus on optimizing the management of schizophrenia. These data include the identification of strategies with novel mechanisms of action (MOAs) to effectively resolve symptoms and promote recovery while minimizing metabolic effects. The second episode of this schizophrenia CMEOcast podcast series explores the MOAs of current and emerging therapies for schizophrenia. Expert faculty ...
CME Outfitters

Clinical Insights on Recent Advances in Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a leading, fatal, autosomal recessive disorder that affects approximately one in 10,000 live births. Nusinersen was approved as the first targeted therapy for SMA, and since its groundbreaking approval data has been published that demonstrates its efficacy for both infantile- and later-onset SMA populations. Additionally, recent guidelines were published that provide evidence-based recommendations for the diagnosis and management of SMA. However, despite the...
CME Outfitters

Food Allergy: From Primary Prevention to Treatment and Intervention Online

This online offering includes 19 videos of lectures and panel discussions on the diagnosis and management, specific syndromes, treatment, and research and prevention of food allergy. The videos were recorded at a live course that took place at a live AAAAI course held in early September, 2019. The intent of the videos is to allow learners to increase their knowledge related to the diagnosis and management of food allergic patients. It highlights the latest evidence related to food allergie...
American Academy of Allergy, Asthma & Immunology

Optimizing the Clinical Outcomes of Patients With Immune Thrombocytopenia

STATEMENT OF NEED Immune thrombocytopenia (ITP) is a heterogeneous disorder with variable clinical features that range from asymptomatic thrombocytopenia to bothersome bruising to life-threatening intracranial hemorrhage. The lack of specific diagnostic criteria remains an important unmet need. Bleeding events are the most common clinical manifestation of ITP but are unpredictable with current laboratory testing. Many patients do not exhibit significant bleeding even in the setting of sever...
i3 Health

Conversations from the World of Allergy: Podcast Episodes for Credit

This podcast features interviews on a wide variety of allergy/immunology topics. It is our hope that the conversations provide evidence-based information that is useful to clinicians, researchers and patients, alike. Some episodes are available for CME credit. All podcast episodes are available at https://www.aaaai.org/professional-education-and-training/podcasts
American Academy of Allergy, Asthma & Immunology

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